Studying Mitosis in Frog extracts and embryos

Xenopus animal caps injected with GFP INCENP and an RFP-CAAX box

Much of our work is done in Human tissue culture cells but these cells are often transformed and they do not exist in tissues. The Stukenberg lab has developed techniques to follow mitosis in developing embryos of the frog Xenopus laevis. This system allows us to complement our tissue culture work by studying mitosis in non-transformed vertebrate tissues.

Mitosis in vertebrate tissues

Building the Xenopus ORFeome

The frog Xenopus laevis has been an important model organism for biological research for over 100 years. To ensure that the system remains viable Todd leads an international consortium to build the Xenopus ORFeome, which will enable exciting frog experiments for the next hundred years. For more information: (http://www.xenbase.org/reagents/static/orfeome.jsp)