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Mechanisms of Chromosomal Instability in Cancer
Chromosomal Instability in Cancer
Almost all cancer cells have some form of genetic instability, which allows them to accumulate mutations to drive tumor progression. A major form of genetic instability is Numerical Chromosomal instability (CIN) where tumor cells missegregate a chromatid approximately once every three or four divisions. As experts in mitosis we are in an outstanding position to study how breast cancer cells develop chromosome instability. We are also developing new prognostic tests to measure CIN in tumors, which we hypothesize will allow doctors to choose the best treatment for their patients.
How do cancer cells reduce the fidelity of mitosis to evolve?
Methods to segregate tumors by CIN status using genome sequencing and by immunohistochmistry
We are developing simple, yet robust, methods to measure CIN in breast tumors. These will be used as personalized medicine tools to answer whether knowing the CIN status can help doctors choose the best treatment regiment. We are both developing methods to repurpose the current tests for Her2 amplification and also to use whole genome/exome sequencing (in collaboration with Ira Hall Wash U. Genome Center) to measure CIN .
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